A brief history of genetic variation analysis
2002 (English)In: BioTechniques, ISSN 0736-6205, Vol. 32, no 5, 1122-+ p.Article, review/survey (Refereed) Published
As the human genome sequence is determined, there is an emerging need for the analysis of human sequence variations as genetic markers in diagnosis, linkage and association studies, cancer research, and pharmacogenomics. There are several different techniques and approaches for detecting these genetic variations, and here we review some of these techniques and their application fields. However, all the techniques have advantages and disadvantages, and factors such as laboratory instrumentation, personnel experience, required accuracy, required throughput, and cost often have to be taken into account before selecting a method.
Place, publisher, year, edition, pages
2002. Vol. 32, no 5, 1122-+ p.
polymerase-chain-reaction, single-nucleotide polymorphisms, gradient gel-electrophoresis, tumor-suppressor gene, sickle-cell anemia, beta-globin gene, mutation detection, point mutations, human genome, oligonucleotide probes
IdentifiersURN: urn:nbn:se:kth:diva-21520ISI: 000175397900021OAI: oai:DiVA.org:kth-21520DiVA: diva2:340218
QC 201005252010-08-102010-08-10Bibliographically approved