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Degradable polymer microspheres for controlled drug delivery
KTH, Superseded Departments, Polymer Technology.ORCID iD: 0000-0002-1631-1781
2002 (English)In: Advances in Polymer Science, ISSN 0065-3195, E-ISSN 1436-5030, Vol. 157, 67-112 p.Article, review/survey (Refereed) Published
Abstract [en]

Controlled drug delivery technology is concerned with the systematic release of a pharmaceutical agent to maintain a therapeutic level of the drug in the body for a sustained period of time. This may be achieved by incorporating the therapeutic agent into a degradable polymer vehicle, releasing the agent continuously as the matrix erodes. This review is concerned with degradable polymers for use in controlled drug delivery with emphasis on the preparation, applications, biocompatibility, and stability of microspheres from hydrolytically degradable polymers.

Place, publisher, year, edition, pages
2002. Vol. 157, 67-112 p.
Keyword [en]
controlled drug delivery, drug release, microspheres, degradation, erosion, polylactide, poly(glycolide-co-lactide), poly(epsilon-caprolactone), poly(hydroxyalkanoates), polyanhydrides, polycarbonates, poly(orthoesters), poly(1,5-dioxepan-2-one), ring-opening polymerization, hydroxybutyrate-hydroxyvalerate copolymers, in-vivo evaluation, biodegradable medical devices, poly(d,l-lactic-co-glycolic acid) microspheres, phosphate-buffered solution, co-glycolide microspheres, bovine serum-albumin, human growth-hormone, controlled-release
URN: urn:nbn:se:kth:diva-21686ISI: 000176673500003OAI: diva2:340384
QC 20100525Available from: 2010-08-10 Created: 2010-08-10Bibliographically approved

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