Change search
ReferencesLink to record
Permanent link

Direct link
New selective method for quantification of organosilanol groups in silicone pre-elastomers
KTH, Superseded Departments, Polymer Technology.
2002 (English)In: Biomacromolecules, ISSN 1525-7797, E-ISSN 1526-4602, Vol. 3, no 4, 850-856 p.Article in journal (Refereed) Published
Abstract [en]

The silicone elastomers used for drug delivery are normally reinforced by fumed silica, which contains a high density of silanol groups. These inorganic silanol groups have to be deactivated in order to avoid stiffening the uncured pre-elastomer. also called creep hardening. One commonly used way of achieving this deactivation is to mix the material with low molecular mass organosilanols at an elevated temperature, It is important to be able to quantify the nonbonded organosilanols remaining in the material after manufacture. Traditional testing does not distinguish between inorganic silanols and organosilanols, A new selective method for the quantification of organosilanol groups in silicone pre-elastomers has therefore been developed, This method is based on derivatization of the silanol groups with a Mixture of dimethylphenylchlorosilane and tetramethyldiphenylsilazane, so that the silanol group, are replaced with a dimethylphenyl group. The derivatized organosilanols are then determined by liquid chromatography using a size exclusion column and a UV detector. No interference was found from other groups normally present in medical grade pre-elastomers, such as vinyls, hydrides, and inorganic bonded silanol on silica or water. The results agreed well with the nonselective Karl Fischer titration for some short chain silanols.

Place, publisher, year, edition, pages
2002. Vol. 3, no 4, 850-856 p.
URN: urn:nbn:se:kth:diva-21695DOI: 10.1021/bm025531pISI: 000176716700030OAI: diva2:340393
QC 20100525Available from: 2010-08-10 Created: 2010-08-10Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Albertsson, Ann-Christine
By organisation
Polymer Technology
In the same journal

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 23 hits
ReferencesLink to record
Permanent link

Direct link