Sensitivity to interstimulus interval due to calcium interactions in the Purkinje cell spines
2002 (English)In: Neurocomputing, ISSN 0925-2312, Vol. 44, 13-18 p.Article in journal (Refereed) Published
Pairing specific LTD (PSD) is produced by paired parallel fiber (PF) and climbing fiber (CF) stimulation and requires Ca2+ elevation. CF or PF activation cause Ca2+ increase through voltage dependent channels and IP3 induced Ca2+ release, respectively. We developed a model of Ca2+ dynamics in Purkinje cell spines to investigate why paired PF-CF activation is necessary for PSD. Simulations show a supralinear increase of the Ca2+ signal if the CF input occurs in a restricted time interval following the PF input. Ca2- buffers significantly contribute to this phenomenon. This mechanism may be involved in the requirement of temporal specificity in classical conditioning.
Place, publisher, year, edition, pages
2002. Vol. 44, 13-18 p.
classical conditioning, Purkinje cells, IP3 induced Ca2+ release, Ca2+ buffers, LTD, long-term depression, neurons, ca2+, insp(3), release, rabbit
IdentifiersURN: urn:nbn:se:kth:diva-21717ISI: 000176839200004OAI: oai:DiVA.org:kth-21717DiVA: diva2:340415
QC 201005252010-08-102010-08-10Bibliographically approved