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Development of micromachined hollow tips for protein analysis based on nanoelectrospray ionization mass spectrometry
KTH, Superseded Departments, Chemistry.
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2002 (English)In: Journal of Micromechanics and Microengineering, ISSN 0960-1317, E-ISSN 1361-6439, Vol. 12, no 5, 682-687 p.Article in journal (Refereed) Published
Abstract [en]

Two novel types of micromachined nanoelectrospray emitter tips have been designed, fabricated and tested. The fabrication method of the hollow tips is based on a self-aligning deep reactive ion etch process. The tips consist of either silicon dioxide or silicon and feature orifice diameters of 10 and 18 mum, respectively. The geometrical characteristics of both emitter types are favorable for the generation of stable electrospray ionization, i.e. wetting of the tip shaft is avoided and the base of the Taylor cone is limited to the diameter of the orifice. A silicon dioxide tip was operated in a bench top setup to visually evaluate the electrospray. Both types of tips were also successfully used for the analysis of an insulin sample in an ion trap mass spectrometer.

Place, publisher, year, edition, pages
2002. Vol. 12, no 5, 682-687 p.
Keyword [en]
microfabricated device, electrospray source, ion-source, chip, beam
URN: urn:nbn:se:kth:diva-21925ISI: 000178281200026OAI: diva2:340623
QC 20100525Available from: 2010-08-10 Created: 2010-08-10Bibliographically approved

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