Synthesis and in vitro degradation of poly(N-vinyl-2-pyrrolidone)-based graft copolymers for biomedical applications
2002 (English)In: Journal of Polymer Science Part A: Polymer Chemistry, ISSN 0887-624X, E-ISSN 1099-0518, Vol. 40, no 21, 3652-3661 p.Article in journal (Refereed) Published
This work is devoted to the design of a novel family of hydrosoluble biomaterials: poly(N-vinyl-2-pyrrolidone) (PVP)-based graft copolymers. A synthesis route has been elaborated in which omega-functionalized PVP is prepared via chain-transfer radical polymerization, end-group modified, and subsequently grafted onto a polyhydroxylated backbone, typically dextran or poly(vinyl alcohol). The resulting graft copolymer biomaterials are designed for use in various biomedical applications, particularly as materials with a stronger potential for plasma expansion than already existing products have. The graft copolymers are potentially degradable because the PVP grafts are connected to the polyol backbone via a hydrolytically labile carbonate or ester linkage. The degradation of the graft copolymers was performed in vitro over a period of 6 weeks.
Place, publisher, year, edition, pages
2002. Vol. 40, no 21, 3652-3661 p.
poly(vinyl pyrrolidone) (PVP), biomaterial, graft copolymer, dextran, degradation, expanders, oligomers, nmr
IdentifiersURN: urn:nbn:se:kth:diva-21963DOI: 10.1002/pola.10468ISI: 000178546200011OAI: oai:DiVA.org:kth-21963DiVA: diva2:340661
QC 201005252010-08-102010-08-10Bibliographically approved