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Replacing the no-effect level (NOEL) with bounded effect levels (OBEL and LEBEL)
KTH, Superseded Departments, History of Science and Technology.
2002 (English)In: Statistics in Medicine, ISSN 0277-6715, E-ISSN 1097-0258, Vol. 21, no 20, 3071-3078 p.Article in journal (Refereed) Published
Abstract [en]

From experiments or epidemiological studies designed to search for a particular toxic effect, it is in general possible to determine an upper bound for that effect. This observed bounded effect level (OBEL) is defined for both positive and negative experiments. It is non-zero even for negative experiments, and it is inversely related to the size of the exposed group. The OBEL can be used to determine the linearly extrapolated bounded effect level (LEBEL) for various effect doses. Contrary to no-observed-effect' levels (NOELs), LEBEL values are designed to protect against type 11 (false negative) errors. It is proposed that LEBEL values replace NOELs as a tool for decision-making.

Place, publisher, year, edition, pages
2002. Vol. 21, no 20, 3071-3078 p.
Keyword [en]
NOEL, no-effect level, OBEL, LEBEL, bounded effect level, type II errors, risk, uncertainty, exposure, safety
URN: urn:nbn:se:kth:diva-21967DOI: 10.1002/sim.1220ISI: 000178591400006OAI: diva2:340665
QC 20100525Available from: 2010-08-10 Created: 2010-08-10Bibliographically approved

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Hansson, Sven Ove
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