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Subcellular interactions between parallel fibre and climbing fibre signals in Purkinje cells predict sensitivity of classical conditioning to interstimulus interval
KTH, Superseded Departments, Numerical Analysis and Computer Science, NADA.ORCID iD: 0000-0002-0550-0739
2002 (English)In: Integrative Physiological & Behavioral Science, ISSN 1053-881X, E-ISSN 2168-7846, Vol. 37, no 4, 265-292 p.Article in journal (Refereed) Published
Abstract [en]

Classical conditioning of the nictitating membrane response requires a specific temporal interval between conditioned stimulus and unconditioned stimulus, and produces an increase in Protein Kinase C (PKC) activation in Purkinje cells. To evaluate whether biochemical interactions within the Purkinje cell may explain the temporal sensitivity, a model of PKC activation by Ca2+, diacylglycerol (DAG), and arachidonic acid (AA) is developed. Ca2+ elevation is due to CF stimulation and IP3 induced Ca2+ release (IICR). DAG and IP3 result from PF stimulation, while AA results from phospholipase A2 (PLA(2)). Simulations predict increased PKC activation when PF stimulation precedes CF stimulation by 0.1 to 3 s. The sensitivity of IICR to the temporal relation between PF and CF stimulation, together with the buffering system of Purkinje cells, significantly contribute to the temporal sensitivity.

Place, publisher, year, edition, pages
2002. Vol. 37, no 4, 265-292 p.
Keyword [en]
classical conditioning, Purkinje cell, protein kinase C, IP3 induced calcium release, computer modeling, LTD, long-term depression, inositol 1,4,5-trisphosphate, calcium, membrane, range
Identifiers
URN: urn:nbn:se:kth:diva-22304ISI: 000181422200003OAI: oai:DiVA.org:kth-22304DiVA: diva2:341002
Note
QC 20100525Available from: 2010-08-10 Created: 2010-08-10 Last updated: 2017-12-12Bibliographically approved

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Hellgren Kotaleski, Jeanette

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