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Characterization of paracetamol agglomerates by image analysis and strength measurement
KTH, Superseded Departments, Chemical Engineering and Technology.
2003 (English)In: Powder Technology, ISSN 0032-5910, E-ISSN 1873-328X, Vol. 130, no 03-jan, 298-306 p.Article in journal (Refereed) Published
Abstract [en]

Paracetamol is crystallized in different solvents and techniques are developed and used to characterize the product. The product particles from three different solvent compositions: ethylene glycol, acetone and an acetone-water mixture (30-70 wt.%) have been examined. Product properties visually observed are quantified by image analysis and evaluation of measured image descriptors with Principal Component Analysis (PCA). The agglomerate strength has been determined by crushing single agglomerates. Depending on the solvent, the content of single crystals and agglomerates differ. Agglomerates differ by the number and size of crystals grown together, as well as by the strength.

Place, publisher, year, edition, pages
2003. Vol. 130, no 03-jan, 298-306 p.
Keyword [en]
crystallization, agglomeration, image analysis, PCA, crushing strength, particle morphology, quantification, solubility, mixtures, crystals, binary, shape
Identifiers
URN: urn:nbn:se:kth:diva-22348ISI: 000181711900045OAI: oai:DiVA.org:kth-22348DiVA: diva2:341046
Note
QC 20100525Available from: 2010-08-10 Created: 2010-08-10 Last updated: 2017-12-12Bibliographically approved

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