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Science and transscience in carcinogen risk assessment - The European Union regulatory process for trichloroethylene
KTH, Superseded Departments, History of Science and Technology.
2003 (English)In: Journal of toxicology and environmental health. Part B, Critical reviews, ISSN 1093-7404, E-ISSN 1521-6950, Vol. 6, no 3, 257-277 p.Article, review/survey (Refereed) Published
Abstract [en]

This is a study of carcinogen risk assessment of the chlorinated solvent trichloroethylene within the European Union existing substances program and the classification and labeling process. The focus is on the most active and influential participants of this process, namely, those from the United Kingdom, Germany, and Sweden, and from industry. The member state and other experts have different opinions regarding the appropriate classification of trichloroethylene for mutagenicity (no classification or category 3) and carcinogenicity (category 3, 2, or 1). In this article these differences are described, as well as how the primary carcinogenicity and mutagenicity data have been interpreted and evaluated by these participants. It is concluded that underlying the different assessments are disagreements about issues that to some degree lie outside the scope of purely scientific considerations.

Place, publisher, year, edition, pages
2003. Vol. 6, no 3, 257-277 p.
Keyword [en]
workers, cohort, mice, mutation
URN: urn:nbn:se:kth:diva-22365DOI: 10.1080/10937400390155599ISI: 000181838800003OAI: diva2:341063
QC 20100525Available from: 2010-08-10 Created: 2010-08-10Bibliographically approved

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Rudén, Christina
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