New PVC materials for medical applications - the release profile of PVC/polycaprolactone-polycarbonate aged in aqueous environments
2003 (English)In: Polymer degradation and stability, ISSN 0141-3910, E-ISSN 1873-2321, Vol. 80, no 3, 451-458 p.Article in journal (Refereed) Published
Medical grade PVC plasticised with polycaprolactone-polycarbonate (PCL-PC) was subjected to aqueous environments at different temperatures. The release profile during ageing was determined by solid phase microextraction (SPME) and GC-MS. At the same time changes in the surface composition due to, for example, migration of PCL-PC from the blend were followed by FTIR. Almost no changes in the material or its surface composition were observed during 98 days at 37 degreesC in water or phosphate buffer. Only trace amount of 6-hydroxyhexanoic acid the final hydrolysis product of PCL-PC was detected in the GC-MS chromatograms and the weight loss was negligible. Even when the ageing temperature was raised to 70 degreesC only minor increase in the amount of 6-hydroxyhexanoic acid was observed and the weight loss after 98 days was under 1%. Changes in the FTIR spectra indicating migration of PCL-PC towards the surface of the PVC/PCL-PC tubing were observed first after 70 days at 70 degreesC. Large increase in the hydrolysis rate of PCL-PC and almost complete depletion of PCL-PC from the blend was observed when the ageing temperature was raised to 100 degreesC.
Place, publisher, year, edition, pages
2003. Vol. 80, no 3, 451-458 p.
PVC, polyester, polycarbonate, low molecular weight compounds, SPME, chromatography mass-spectrometry, solid-phase microextraction, molecular-weight changes, degradation products, plasticized films, poly(vinyl chloride), polyester blends, migration, foods, di-(2-ethylhexyl)adipate
Polymer Technologies Polymer Chemistry
IdentifiersURN: urn:nbn:se:kth:diva-22470DOI: 10.1016/S0141-3910(03)00029-6ISI: 000182635800007OAI: oai:DiVA.org:kth-22470DiVA: diva2:341168
QC 20100525 NR 201408042010-08-102010-08-102012-02-01Bibliographically approved