Change search
ReferencesLink to record
Permanent link

Direct link
Experimental study for agglomeration behaviour of paracetamol in acetone-toluene-water systems
KTH, Superseded Departments, Chemical Engineering and Technology.
2003 (English)In: Chemical engineering research & design, ISSN 0263-8762, E-ISSN 1744-3563, Vol. 81, no A4, 489-495 p.Article in journal (Refereed) Published
Abstract [en]

Agglomeration behaviour of paracetamol was studied in acetone-toluene-water systems. The aim was to experimentally determine how the solvent composition influences the agglomeration tendency of paracetamol. It was found that for the chosen solvent system there is one main region where paracetamol agglomerates: the region with large amounts of acetone (>65 wt%) and very small amounts of water (<4 wt%). The same behaviour can be observed both within the one-phase region and within the two-phase region. The experimental agglomeration results were compared with molecular simulations from literature. Both methods indicate that it is more likely for paracetamol crystals to agglomerate in organic systems than in aqueous systems.

Place, publisher, year, edition, pages
2003. Vol. 81, no A4, 489-495 p.
Keyword [en]
paracetamol, agglomeration, solvent composition, binary solvent mixtures, acetaminophen, growth
URN: urn:nbn:se:kth:diva-22478ISI: 000182691100009OAI: diva2:341176
QC 20100525Available from: 2010-08-10 Created: 2010-08-10Bibliographically approved

Open Access in DiVA

No full text

Search in DiVA

By author/editor
Rasmuson, Åke C.
By organisation
Chemical Engineering and Technology
In the same journal
Chemical engineering research & design

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Total: 25 hits
ReferencesLink to record
Permanent link

Direct link