Role of A-current in lamprey locomotor network neurons
2003 (English)In: Neurocomputing, ISSN 0925-2312, Vol. 52-54, 295-300 p.Article in journal (Refereed) Published
A compartmental model of lamprey central pattern generator neurons was built in order to examine the effects of a fast, transient, high-voltage-activated potassium current (A-current) found experimentally. The model consisted of a soma, a compartment corresponding to the axon initial segment, and a dendritic tree. The simulation showed that the A-current was necessary for repetitive spiking in the single neuron following current injection. The functional role of adding an A-current was also examined in a network model. In this model, the A-current stabilizes the swimming rhythm by making the burst cycle duration and the number of spikes per burst less variable. All these effects are also seen experimentally.
Place, publisher, year, edition, pages
2003. Vol. 52-54, 295-300 p.
A-current, lamprey, potassium, CPG, Hodgkin-Huxley
IdentifiersURN: urn:nbn:se:kth:diva-22590DOI: 10.1016/s0925-2312(02)00784-1ISI: 000183514300044OAI: oai:DiVA.org:kth-22590DiVA: diva2:341288
QC 20100525 QC 201112292010-08-102010-08-102011-12-29Bibliographically approved