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Evaluation of generic chiral liquid chromatography screens for pharmaceutical analysis
KTH, Superseded Departments, Chemistry.
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2003 (English)In: Journal of Chromatography A, ISSN 0021-9673, E-ISSN 1873-3778, Vol. 1005, no 02-jan, 83-101 p.Article in journal (Refereed) Published
Abstract [en]

Two different automated generic liquid chromatography screens for the separation of chiral compounds of pharmaceutical interest have been evaluated. The test set comprised 53 chemically diverse chiral compounds involving 55 enantiomeric pairs from the pharmaceutical industry (i.e. starting materials, synthetic intermediates and drug substances). The first screen utilised four polysaccharide-based columns with five mobile phases and showed enantioselectivity for 87% of the test compounds. The second screen employed three macrocyclic glycopeptide columns with two mobile phases and showed enantioselectivity for 65% of the test compounds. Merging of the two screening procedures resulted in an enantioselectivity for 96% of the chiral compounds. It is anticipated that the systematic use of the automated chiral HPLC screens described in this report will substantially reduce the necessary time for method development of pharmaceutically related chiral analytical methods.

Place, publisher, year, edition, pages
2003. Vol. 1005, no 02-jan, 83-101 p.
Keyword [en]
pharmaceutical analysis, chiral stationary phases, LC, enantiomer separation, stationary phases, phenylalanine analogs/, optical resolution, separation, cellulose, enantiomers, hplc, enantioseparation, derivatives, additives
URN: urn:nbn:se:kth:diva-22688DOI: 10.1016/s0021-9673(03)00888-4ISI: 000184296800007OAI: diva2:341386
QC 20100525Available from: 2010-08-10 Created: 2010-08-10Bibliographically approved

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Roeraade, Johan
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