Scrutinizing ACGIH risk assessments: The trichloroethylene case
2003 (English)In: American Journal of Industrial Medicine, ISSN 0271-3586, E-ISSN 1097-0274, Vol. 44, no 2, 207-213 p.Article in journal (Refereed) Published
Background The American Conference of Governmental Industrial Hygienists (ACGIH) threshold limit values (TLVs)for occupational exposure to chemicals and physical agents have been very influential in the setting of occupational exposure limits in many countries. Methods Three ACGIH risk assessments of the chlorinated solvent trichloroethylene (TCE) [ACGIH (1989): 5th edition; ACGIH (1992): 5th edition. Revised Vol II; ACGIH (1996): Suppl. 6th edition] are compared to 26 other risk assessments made of the same chemical substance. The documents are compared in terms of their overall conclusions and the data selected for assessment. Results It is shown that these ACGIH risk assessment documents were based on incomplete and biased data sets. Conclusions The data on which the ACGIH [ACGIH (1996): Suppl. 6th edition] base their TCE risk assessment do not adequately reflect the available scientific knowledge about TCE toxicity and carcinogenicity. This may have influenced their conclusion that TCE is not carcinogenic in either animals or humans which stand out compared to contemporary risk assessments.
Place, publisher, year, edition, pages
2003. Vol. 44, no 2, 207-213 p.
regulatory toxicology, carcinogenicity, risk management, threshold limit values, threshold limit values, chemical reactivity, european-union, exposure, cell, carcinogenicity, cohort, tumors, mode
IdentifiersURN: urn:nbn:se:kth:diva-22703DOI: 10.1002/ajim.10252ISI: 000184424000012OAI: oai:DiVA.org:kth-22703DiVA: diva2:341401
QC 201005252010-08-102010-08-10Bibliographically approved