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How accurate are the European Union's classifications of chemical substances
KTH, Superseded Departments, History of Science and Technology.
KTH, Superseded Departments, History of Science and Technology.
2003 (English)In: Toxicology Letters, ISSN 0378-4274, E-ISSN 1879-3169, Vol. 144, no 2, 159-172 p.Article in journal (Refereed) Published
Abstract [en]

The European Commission has decided on harmonized classifications for a large number of individual chemicals according to its own directive for classification and labeling of dangerous substances. We have compared the harmonized classifications for acute oral toxicity to the acute oral toxicity data available in the RTECS database. Of the 992 substances eligible for this comparison, 15% were assigned a too low danger class and 8% a too high danger class according to the RTECS data. Due to insufficient transparency-scientific documentations of the classification decisions are not available-the causes of this discrepancy can only be hypothesized. We propose that the scientific motivations of future classifications be published and that the apparent over- and underclassifications in the present system be either explained or rectified, according to what are the facts in the matter.

Place, publisher, year, edition, pages
2003. Vol. 144, no 2, 159-172 p.
Keyword [en]
regulatory toxicology, risk assessment, risk management, mis-classifications, classification and labelling
URN: urn:nbn:se:kth:diva-22839DOI: 10.1016/s0378-4274(03)00204-2ISI: 000185544400003OAI: diva2:341537
QC 20100525Available from: 2010-08-10 Created: 2010-08-10Bibliographically approved

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Rudén, ChristinaHansson, Sven Ove
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