Change search
ReferencesLink to record
Permanent link

Direct link
Neural stem cells: A potential source for remyelination in neuroinflammatory disease
Show others and affiliations
2003 (English)In: Brain Pathology, ISSN 1015-6305, E-ISSN 1750-3639, Vol. 13, no 3, 322-328 p.Article in journal (Refereed) Published
Abstract [en]

In multiple sclerosis, the central nervous system is lesioned through invasion of plaque-forming inflammatory cells, primarily contributing to immune attack of myelin and oligodendrocytes. In this report we address the possible activation and differentiation of central nervous system stem cells following such immunological insults in a well-characterized rat model of multiple sclerosis characterised by spinal cord pathology. Dye-labeled central nervous system stem cells, residing within the ependymal layer of the central canal responded to the multiple sclerosis-like conditions by proliferation, while some of the migrating stem cell-derived cells expressed markers typical for oligodendrocytes (04) and astrocytes (glial fibrillary acidic protein, GFAP) in the demyelinated area. Our results indicate that regenerative stem cell activation following immunoactivity is different from that after trauma, exemplified by the slower time course of stem cell proliferation and migration of progeny, in addition to the ability of the stem cell-derived cells to express oligodendrocyte markers. Finally,, deleterious effects of macrophages on the stem cell population were evident and may contribute to the, depletion of the stem cell population in neuroinflammatory disorders.

Place, publisher, year, edition, pages
2003. Vol. 13, no 3, 322-328 p.
Keyword [en]
central-nervous-system, experimental autoimmune encephalomyelitis, rat spinal-cord, multiple-sclerosis, growth-factor, lesions, proliferation, progenitors, injury, differentiation
URN: urn:nbn:se:kth:diva-22966ISI: 000186614100008OAI: diva2:341664
QC 20100525Available from: 2010-08-10 Created: 2010-08-10Bibliographically approved

Open Access in DiVA

No full text

Search in DiVA

By author/editor
Brismar, Hjalmar
In the same journal
Brain Pathology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Total: 35 hits
ReferencesLink to record
Permanent link

Direct link