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Dynamic combinatorial carbohydrate libraries: Probing the binding site of the concanavalin A lectin
KTH, Superseded Departments, Chemistry.
2004 (English)In: Chemistry - A European Journal, ISSN 0947-6539, E-ISSN 1521-3765, Vol. 10, no 7, 1711-1715 p.Article in journal (Refereed) Published
Abstract [en]

Dynamic combinatorial chemistry (DCC) has emerged as an efficient approach to receptor/ligand identification based on the generation of combinatorial libraries by reversible interconversion of the library constituents. In this study, the implementation of such libraries on carbohydrate-lectin interactions was examined with the plant lectin Concanavalin A as a target species. Dynamic carbohydrate libraries were generated from a pool of carbohydrate aldehydes and hydrazide linker/scaffold components through re- versible acylhydrazone exchange, resulting in libraries containing up to 474 constituents. Dynamic deconvolution allowed the efficient identification of the structural features required for binding to Concanavalin A and the selection of a strong binder, a tritopic mannoside, showing an IC50-value of 22 mum.

Place, publisher, year, edition, pages
2004. Vol. 10, no 7, 1711-1715 p.
Keyword [en]
carbohydrates, combinatorial chemistry, concanavalin A, glycoconjugates, receptors, galnac-specific lectins, molecular recognition, chemical evolution, generation, amplification, inhibitors, chemistry, helicate, dendrimers, component
National Category
Chemical Sciences
URN: urn:nbn:se:kth:diva-23323DOI: 10.1002/chem.200305551ISI: 000220771700014ScopusID: 2-s2.0-1842784768OAI: diva2:342021
QC 20100525Available from: 2010-08-10 Created: 2010-08-10 Last updated: 2011-10-31Bibliographically approved

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