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Lack of association of human chemokine receptor gene polymorphisms CCR2-64I and CCR5-Delta 32 with autoimmune Addison's disease
KTH, Superseded Departments, Biotechnology.
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2004 (English)In: European journal of immunogenetics, ISSN 0960-7420, E-ISSN 1365-2370, Vol. 31, no 2, 73-76 p.Article in journal (Refereed) Published
Abstract [en]

The attraction of leukocytes to tissues is essential for inflammation and the initiation of the autoimmune reaction. The process is controlled by chemokines, which are chemotactic cytokines. We investigated whether human chemokine receptor gene polymorphisms, namely CCR5-Delta32 and CCR2-64I, are associated with susceptibility to autoimmune Addison's disease. Genotyping was performed in 56 patients and 127 healthy controls by a new method using pyrosequencing for CCR2-64I and by polymerase chain reaction and detecting gel for CCR5-Delta32. None of the CCR2 or CCR5 alleles was found to be associated, either positively or negatively, with disease risk. Our results indicate that the CCR2-64I and CCR5-Delta32 gene polymorphisms do not play a major role in conferring genetic risk for, and/or protection against, autoimmune Addison's disease.

Place, publisher, year, edition, pages
2004. Vol. 31, no 2, 73-76 p.
Keyword [en]
adrenal insufficiency, progression, infection, genotype, alleles, risk
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URN: urn:nbn:se:kth:diva-23337DOI: 10.1111/j.1365-2370.2004.00447.xISI: 000220856700003ScopusID: 2-s2.0-2342526484OAI: diva2:342035
QC 20100525 QC 20111028Available from: 2010-08-10 Created: 2010-08-10 Last updated: 2011-10-28Bibliographically approved

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