Polymer-assisted laser desorption/ionization analysis of small molecular weight compounds
2004 (English)In: Rapid Communications in Mass Spectrometry, ISSN 0951-4198, E-ISSN 1097-0231, Vol. 18, no 8, 841-852 p.Article in journal (Refereed) Published
The use of non-polar, small polymers as matrices for the analysis of low molecular weight compounds in polymer-assisted laser desorption/ionization mass spectrometry (PALDI-MS) is demonstrated. The matrices evaluated were either based on an oligothiophene or a benzodioxin backbone. Metallocenes, polycyclic hydrocarbons, a fluorosurfactant, and a subset of small organic compounds with various functionalities, served as model analytes. The mechanism of ionization charge transfer is discussed and ionization potentials for the matrices in the study have been estimated using density functional theory (DFT) calculations. Some of the results are possibly contradictory to the generally accepted limiting conditions for gas-phase charge-transfer reactions. These results are interpreted in the light of energy pooling. Also a new mass calibration procedure for the lowmass region in positive ion mode is presented, and some aspects of the ionization/desorption process leading to radical cations are studied.
Place, publisher, year, edition, pages
2004. Vol. 18, no 8, 841-852 p.
flight mass-spectrometry, maldi-tof-ms, desorption-ionization, quantitative-analysis, delayed extraction, porous silicon, ion formation, matrix, time, velocity
IdentifiersURN: urn:nbn:se:kth:diva-23350DOI: 10.1002/rcm.1412ISI: 000220963900003PubMedID: 15095351ScopusID: 2-s2.0-1942502816OAI: oai:DiVA.org:kth-23350DiVA: diva2:342048
QC 20100525 QC 201111012010-08-102010-08-102016-04-11Bibliographically approved