Intrinsic desynchronization properties of neurons containing dendritic rapidly activating K-currents
2004 (English)In: Neurocomputing, ISSN 0925-2312, Vol. 58, 137-143 p.Article in journal (Refereed) Published
In this work, we investigate the role of the potassium A-current (K-A) in linking network synchrony to cellular excitability and firing frequency. We present an analysis of the notion of synchrony and we describe its conceptual and modeling implications. An full synchronization, K-A enables a control over the timing, or even a suppression, of spikes. For completely desynchronized activity, we show how K-A affects fast changes in amplitude of the summed EPSPs as well as amount of depolarization caused by the input. Simulations at intermediate levels of synchrony suggest that activity resulting from the interaction between cellular excitability and network synchrony could be altered through K-A modulation.
Place, publisher, year, edition, pages
2004. Vol. 58, 137-143 p.
synchrony, correlation, excitability, firing frequency, gamma distribution
Neurosciences Bioinformatics (Computational Biology)
IdentifiersURN: urn:nbn:se:kth:diva-23528DOI: 10.1016/j.neucom.2004.01.034ISI: 000222245900022ScopusID: 2-s2.0-2542499805OAI: oai:DiVA.org:kth-23528DiVA: diva2:342226
QC 20100525 QC 20111018. 12th Annual Computational Neuroscience Meeting (CSN 03). Alicante, SPAIN. JUL 05-09, 20032010-08-102010-08-102011-12-14Bibliographically approved