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Intrinsic desynchronization properties of neurons containing dendritic rapidly activating K-currents
KTH, Superseded Departments, Numerical Analysis and Computer Science, NADA.
KTH, Superseded Departments, Numerical Analysis and Computer Science, NADA.ORCID iD: 0000-0003-0281-9450
2004 (English)In: Neurocomputing, ISSN 0925-2312, Vol. 58, 137-143 p.Article in journal (Refereed) Published
Abstract [en]

In this work, we investigate the role of the potassium A-current (K-A) in linking network synchrony to cellular excitability and firing frequency. We present an analysis of the notion of synchrony and we describe its conceptual and modeling implications. An full synchronization, K-A enables a control over the timing, or even a suppression, of spikes. For completely desynchronized activity, we show how K-A affects fast changes in amplitude of the summed EPSPs as well as amount of depolarization caused by the input. Simulations at intermediate levels of synchrony suggest that activity resulting from the interaction between cellular excitability and network synchrony could be altered through K-A modulation.

Place, publisher, year, edition, pages
2004. Vol. 58, 137-143 p.
Keyword [en]
synchrony, correlation, excitability, firing frequency, gamma distribution
National Category
Neurosciences Bioinformatics (Computational Biology)
URN: urn:nbn:se:kth:diva-23528DOI: 10.1016/j.neucom.2004.01.034ISI: 000222245900022ScopusID: 2-s2.0-2542499805OAI: diva2:342226
QC 20100525 QC 20111018. 12th Annual Computational Neuroscience Meeting (CSN 03). Alicante, SPAIN. JUL 05-09, 2003Available from: 2010-08-10 Created: 2010-08-10 Last updated: 2011-12-14Bibliographically approved

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Llorens, Vicente CharcosFransén, Erik
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