Cutting edge: Membrane nanotubes connect immune cells
2004 (English)In: Journal of Immunology, ISSN 0022-1767, E-ISSN 1550-6606, Vol. 173, no 3, 1511-1513 p.Article in journal (Refereed) Published
We present evidence that nanotubular highways, or membrane nanotubes, facilitate a novel mechanism for intercellular communication in the immune system. Nanotubes were seen to connect multiple cells together and were readily formed between a variety of cell types, including human peripheral blood NK cells, macrophages, and EBV-transformed B cells. Nanotubes could be created upon disassembly of the immunological synapse, as cells move apart. Thus, nanotubular networks could be assembled from transient immunological synapses. Nanotubes were seen to contain GFP-tagged cell surface class I MHC protein expressed in one of the connected cells. Moreover, GPI-conjugated to GFP originating from one cell was transferred onto the surface of another at the connection with a nanotube. Thus, nanotubes can traffic cell surface proteins between immune cells over many tens of microns. Determining whether there are physiological functions for nanotubes if an intriguing new goal for cellular immunology.
Place, publisher, year, edition, pages
2004. Vol. 173, no 3, 1511-1513 p.
immunological synapse, t-cells, intercellular transfer, nk cells, organization, networks
IdentifiersURN: urn:nbn:se:kth:diva-23591ISI: 000222807100004OAI: oai:DiVA.org:kth-23591DiVA: diva2:342290
QC 201005252010-08-102010-08-10Bibliographically approved