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Myocardial velocities measured during adenosine, dobutamine and supine bicycle exercise: a tissue Doppler study in healthy volunteers
Dept. of Clin. Physiology/Cardiology, Karolinska Univ. Hosp. at Huddinge.
Dept. of Clin. Physiology/Cardiology, Karolinska Univ. Hosp. at Huddinge.
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2004 (English)In: Clinical Physiology and Functional Imaging, ISSN 1475-0961, E-ISSN 1475-097X, Vol. 24, no 5, 281-288 p.Article in journal (Refereed) Published
Abstract [en]

Background: Dobutamine stress echocardiography (DSE) quantified by tissue Doppler (TVI) have improved the diagnostic capacity of the procedure. Quantification of other stress modalities, e.g. adenosine stress echo (ASE) and exercise stress echocardiography (ESE) are necessary for assessing any pathophysiological differences in different forms of stress. Methods: Ten healthy individuals underwent ASE, DSE, and ESE during a span of 2-5 days. Left ventricular (LV) apical images at rest and peak stress (max) were postprocessed using TVI on a GE System FiVe equipment. ECG-derived QRS duration (QRSD, ms), heart rate (HR, bpm), TVI-estimated basal systolic velocities (S2V, cm s(-1)), ejection time (S2T, ms) and strain (S, %) were computed off-line and compared. Longitudinal displacement imaging, tissue tracking, was also made. Results: Data for ASE, DSE and ESE during peak stress were (HR: 84 +/- 12***, 142 +/- 19, 137 +/- 27; P0.05) response at a much lower HR indicates that adenosine has minor effects on contraction presumably secondary to vasodilatation. Powerful chronotropic response to DSE and ESE is probably prerequisite for strong velocity response at the expense of strain and displacement. TVI-assisted stress echocardiography thereby shows different LV systolic response in healthy individuals, depending on stress modality.

Place, publisher, year, edition, pages
2004. Vol. 24, no 5, 281-288 p.
Keyword [en]
echocardiography, non-pharmacological stress, pharmacological stress, tissue Doppler, coronary-artery-disease, quantitative stress echocardiography, regional systolic function, strain-rate, diastolic function, ischemia, hyperemia, diagnosis
National Category
Medical and Health Sciences
URN: urn:nbn:se:kth:diva-23740DOI: 10.1111/j.1475-097X.2004.00563.xISI: 000224000700006PubMedID: 15383085OAI: diva2:342439
QC 20100525 QC 20120221Available from: 2010-08-10 Created: 2010-08-10 Last updated: 2012-03-23Bibliographically approved

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Brodin, Lars-ÅkeLind, Britta
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