Mathematical modelling on the controlled-release of indomethacin-encapsulated poly(lactic acid-co-ethylene oxide) nanospheres
2004 (English)In: Nanotechnology, ISSN 0957-4484, E-ISSN 1361-6528, Vol. 15, no 9, 1186-1194 p.Article in journal (Refereed) Published
The in vitro release behaviour of indomethacin (IMC, 1-[p-chlorobenzoyl]-2-methyl-5-methoxy-3-indoleacetic acid) encapsulated in poly(lactic acid-co-ethylene oxide) (PLA-PEO) nanospheres is investigated based on two mathematical models: the diffusion model derived from Fick's law and the dissolution model from the mass balance of IMC. A dual chamber transport system (DCTS) is designed and used for the in vitro experiment. The release behaviour of IMC from the PLA-PEO drug delivery systems (DDSs) is compared to the mathematical models suggested in this work. The synthesis of PLA-PEO and the fabrication of the IMC-loaded PLA-PEO DDSs are discussed and characterized by H-1 NMR, transmission electron microscopy (TEM) and quasi-elastic light scattering (QELS) spectroscopy. Spherical PLA-PEO nanospheres are well prepared as a model DDS as suggested by the characterization results. The overall releasing behaviour of the model drug can be manipulated by varying several key parameters including the volumetric ratio between the organic and the aqueous phase (V-r), the partition coefficient (K-p) and the encapsulation efficiency (EE). Modelling results show that the releasing mechanism is different depending on the particle size. When large PLA-PEO nanospheres are fabricated, the dissolution mechanism can be effective, as the dissolution of IMC can be a rate-determining step due to its high hydrophobicity in an aqueous surrounding medium. In this manner, the optimum DDS can be suitably designed and the releasing profile can be also estimated by considering several major factors for a specific type of substance and its purpose.
Place, publisher, year, edition, pages
2004. Vol. 15, no 9, 1186-1194 p.
loaded biodegradable nanospheres, methoxy poly(ethylene glycol), drug-release, multiblock copolymers, plga nanoparticles, block-copolymer, microspheres, diffusion, delivery, albumin
IdentifiersURN: urn:nbn:se:kth:diva-23745DOI: 10.1088/0957-4484/15/9/014ISI: 000224022800014ScopusID: 2-s2.0-4544250139OAI: oai:DiVA.org:kth-23745DiVA: diva2:342444
QC 20100525 QC 201109232010-08-102010-08-102012-03-20Bibliographically approved