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Neuromodulatory control of neocortical microcircuits with activity-dependent short-term synaptic depression
KTH, Superseded Departments, Physics.
2004 (English)In: Journal of biological physics (Print), ISSN 0092-0606, E-ISSN 1573-0689, Vol. 30, no 3, 261-284 p.Article in journal (Refereed) Published
Abstract [en]

A biophysical model of a neocortical microcircuit system is formulated and employed in studies of neuromodulatory control of dynamics and function. The model is based on recent observations of reciprocal connections between pyramidal cells and inhibitory interneurons and incorporates a new type of activity-dependent short-term depression of synaptic couplings recently observed. The model neurons are of a low-dimensional type also accounting for neuronal adaptation, i.e. the coupling between neuronal activity and excitability, which can be regulated by various neuromodulators in the brain. The results obtained demonstrate a capacity for neuromodulatory control of dynamical mode linked to functional mode. The functional aspects considered refer to the observed resolution of multiple objects in working memory as well as the binding of different features for the perception of an object. The effects of neuromodulators displayed by the model are in accordance with many observations on neuromodulatory influence on cognitive functions and brain disorders.

Place, publisher, year, edition, pages
2004. Vol. 30, no 3, 261-284 p.
Keyword [en]
neocortical microcircuit dynamics, biophysical model neurons, neuronal adaptation, dynamic synapses, neuromodulation, working memory, cognitive functions, rat visual-cortex, ca1 pyramidal cells, basal forebrain lesions, working-memory, theta-rhythm, neuromuscular junction, acetylcholine-release, transmitter release, alzheimers-disease, cerebral-cortex
National Category
Biophysics
Identifiers
URN: urn:nbn:se:kth:diva-23857DOI: 10.1023/B:JOBP.0000046745.65807.5eISI: 000224857100004Scopus ID: 2-s2.0-7744227204OAI: oai:DiVA.org:kth-23857DiVA: diva2:342556
Note

QC 20100525 QC 20111102

Available from: 2010-08-10 Created: 2010-08-10 Last updated: 2017-12-12Bibliographically approved

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  • apa
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