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Myostatin rapid sequence evolution in ruminants predates domestication
KTH, Superseded Departments, Biotechnology.ORCID iD: 0000-0002-1495-8338
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2004 (English)In: Molecular Phylogenetics and Evolution, ISSN 1055-7903, E-ISSN 1095-9513, Vol. 33, no 3, 782-790 p.Article in journal (Refereed) Published
Abstract [en]

Myostatin (GDF-8) is a negative regulator of skeletal muscle development. This gene has previously been implicated in the double muscling phenotype in mice and cattle. A systematic analysis of myostatin sequence evolution in ruminants was performed in a phylogenetic context. The myostatin coding sequence was determined from duiker (Sylvicapra grimmia caffra), eland (Taurotragus derbianus), gaur (Bos gaurus), ibex (Capra ibex), impala (Aepyceros melampus rednilis), pronghorn (Antilocapra americana), and tahr (Hemitragus jemlahicus). Analysis of nonsynonymous to synonymous nucleotide substitution rate ratios (K-a/K-s) indicates that positive selection may have been operating on this gene during the time of divergence of Bovinae and Antilopinae, starting from approximately 23 million years ago, a period that appears to account for most of the sequence difference between myostatin in these groups. These periods of positive selective pressure on myostatin may correlate with changes in skeletal muscle mass during the same period.

Place, publisher, year, edition, pages
2004. Vol. 33, no 3, 782-790 p.
Keyword [en]
myostatin, positive selection, phylogeny, artiodactyl, skeletal muscle mass, skeletal-muscle mass, positive selection, family bovidae, gene, likelihood, growth, phylogenies, mutations
National Category
Industrial Biotechnology
URN: urn:nbn:se:kth:diva-23883DOI: 10.1016/j.ympev.2004.07.004ISI: 000225206700019ScopusID: 2-s2.0-7444262856OAI: diva2:342582
QC 20100525 QC 20110922Available from: 2010-08-10 Created: 2010-08-10 Last updated: 2011-09-22Bibliographically approved

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