Change search
ReferencesLink to record
Permanent link

Direct link
The role of p53 codon 72 and human papilloma virus status of cutaneous squamous cell carcinoma in the Swedish population
KTH, Superseded Departments, Biotechnology.
Show others and affiliations
2004 (English)In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 84, no 6, 439-444 p.Article in journal (Refereed) Published
Abstract [en]

The arginine variant of the p53 codon 72 polymorphism as well as anogenital and epidermodysplasia verruciformis (EV) types of human papilloma virus (HPV) are suggested to confer increased risk for developing cutaneous squamous cell carcinoma (SCC). In this pilot study, we analysed the p53 codon 72 genotype distribution in 106 microdissected samples from normal and tumour tissues of 53 cases of cutaneous SCC and 96 controls from Sweden. Both normal and tumour samples from cases of SCC were screened for anogenital and EV HPV. The p53(Arg) allele was not associated with the development of cutaneous SCC. Anogenital HPV (44%) was more prevalent than EV HPV (12%). Data also indicate that anogenital HPV is more common in tumour samples, but HPV infection was not identified as a significant risk factor for developing SCC. The presence of anogenital HPV, but not EV HPV might be a risk factor for development of cutaneous SCC.

Place, publisher, year, edition, pages
2004. Vol. 84, no 6, 439-444 p.
Keyword [en]
single nucleotide polymorphism, loss of heterozygozity (LOH), epidermodysplasia verruciformis (EV), anogenital, nonmelanoma skin cancers, renal-transplant recipients, cervical-cancer, 72 polymorphism, e6 proteins, immunocompetent individuals, induced apoptosis, hpv types, low-risk, susceptibility
National Category
Engineering and Technology
URN: urn:nbn:se:kth:diva-23893DOI: 10.1080/00015550410021673ISI: 000225249800005ScopusID: 2-s2.0-12344281513OAI: diva2:342592
QC 20100525 QC 20110915Available from: 2010-08-10 Created: 2010-08-10 Last updated: 2012-03-20Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textScopus

Search in DiVA

By author/editor
Gustafsson, Anna C.Lundeberg, Joakim
By organisation
In the same journal
Acta Dermato-Venereologica
Engineering and Technology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 15 hits
ReferencesLink to record
Permanent link

Direct link