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Synchronous delivery systems composed of Au nanoparticles and stimuli-sensitive diblock terpolymer
KTH, Superseded Departments, Materials Science and Engineering.
2004 (English)In: Journal of materials science. Materials in medicine, ISSN 0957-4530, E-ISSN 1573-4838, Vol. 15, no 12, 1291-1295 p.Article in journal (Refereed) Published
Abstract [en]

A method to construct synchronous delivery systems via direct self-assembly of Au nanoparticles on the poly[(N-isopropylacrylamide-r-acrylamide)-b-L-lactic acid] (PNAL) nanospheres has been presented in this paper. To achieve amphiphilic diblock terpolymer, hydrophobic poly (L-lactic acid) (PLLA) block was added to poly(N-isopropylacrylamide-r-ac rylamide) (PNA) block via Michel-type addition reaction. Lower critical solubility temperature (LCST) was modulated at 35.6 degreesC which is close to the body temperature, but higher than poly(N-isopropylacrylamide) (PNIPAAm) homopolymer by controlling the ratio between isopropylacrylamide (IPAAm) monomers and acrylamide (AAm) monomers. Using this amphiphilic diblock terpolymer, PNAL nanospheres were fabricated by emulsion/evaporation technique followed by direct self-assembly of Au nanoparticles on the PNAL nanospheres due to the high affinity of amino groups donated from PNA block. The 'core' site of Au@)PNAL nanospheres can load various lyphophilic drugs. Moreover, Au nanoparticles in the 'shell' domain of PNAL nanospheres give optimal environment to conjugate various biomolecules. Therefore, it is expected that Au@PNAL hybrid nanospheres can be utilized in synchronous delivery of both biomolecules in the 'shell' domain and various therapeutic drugs in the 'core' domain.

Place, publisher, year, edition, pages
2004. Vol. 15, no 12, 1291-1295 p.
Keyword [en]
colloidal gold nanoparticles, fatty amine molecules, core-shell, drug-delivery, enzymatic-activity, controlled-release, phase-transfer, poly(n-isopropylacrylamide), nanospheres, particles
URN: urn:nbn:se:kth:diva-24007ISI: 000226838200005ScopusID: 2-s2.0-15244352725OAI: diva2:342706
QC 20100525Available from: 2010-08-10 Created: 2010-08-10Bibliographically approved

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Muhammed, Mamoun
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