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Regular hypnotic drug treatment in a sample of 32,679 Swedes: associations with somatic and mental health, inpatient psychiatricdiagnoses and suicide, derived with automated record-linkage
KTH, School of Architecture and the Built Environment (ABE), Transport and Economics, Safety Research.ORCID iD: 0000-0001-7606-8771
1991 (English)In: Psychosomatic Medicine, ISSN 0033-3174, E-ISSN 1534-7796, Vol. 53, no 1, 101-108 p.Article in journal (Refereed) Published
Abstract [en]

We studied Swedish survey responders who reported regular treatment with hypnotic drugs, to find associations to perceived health problems, inpatient psychiatric diagnoses, and subsequent suicide. Among 32,679 sampled Swedes, 26,952 (83%) participated, 500 of which (2%) reported regular hypnotic drug treatment. The rate of treatment was higher in women, and increased by age in both sexes. The major findings were high odds of concurrent psychoactive drug treatments, nervous symptoms and insomnia, as well as high rates of circulatory and musculoskeletal conditions in both sexes, with indicators of disability and sleep-disturbing symptoms. During a 15-year period, 35% of the men and 21% of the women who reported regular hypnotic drug treatment had also been admitted to inpatient psychiatric care. Substance abuse was diagnosed in 20% of the men and 4.3% of the women reporting hypnotic drug treatment. In multiple logistic regression models, the highest odds for regular hypnotic drug treatment were incurred by recent/current insomnia, nervous symptoms, and other psychoactive drug treatment. We conclude that therapy was principally given according to some current peer guidelines. Yet, further research is needed into the risk/benefit ratio of sustained hypnotic drug therapy in patients with qualifying somatic and psychiatric disorders to obtain a more uniformly based consensus.

Place, publisher, year, edition, pages
1991. Vol. 53, no 1, 101-108 p.
URN: urn:nbn:se:kth:diva-24299ISI: A1991EV35000009OAI: diva2:346445
QC20100901Available from: 2010-09-01 Created: 2010-09-01 Last updated: 2010-09-01Bibliographically approved
In thesis
1. Risk, Risk Analysis and Decision-making with Reference to Biostatistics and the Field of Medicine
Open this publication in new window or tab >>Risk, Risk Analysis and Decision-making with Reference to Biostatistics and the Field of Medicine
2010 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Risk, risk analysis and decision-making are essential aspects of health care andmedicine, for patients as well as for physicians and for society as a whole, andthe concept of risk and risk analysis in decision-making has a long history. Theword risk has many different interpretations and has no commonly accepteddefinition. In this thesis, we shall let risk stand for the combination of randomor uncertain events with negative consequences for human health, life and/orwelfare and/or the environment together with some measures of the likelihoodof such events. We believe this is the dominant concept and understanding ofrisk, the risk being the likelihood or probability of an event followed by somenegative consequences or activities of that event.

In this doctoral thesis, we focus on biostatistics, risks and risk analysis in thefield of medicine, a science which has been using methods from the area of riskanalysis for a long time. The seven papers (paper I - paper VII) presented inthis thesis, together with a general introduction to risk, risk analysis anddecision-making, will be used to illustrate and discuss risk analysis as a tool fordecision-making in the field of medicine. From my point a view, risk analysisin the field of medicine aims to reduce pain, raise the quality of life, reduce therisk of adverse events, compare cost efficiency between different treatmentregimes and prolong a healthy life. Based on results presented in the thesis, weconclude that biostatistics, risks and risk analysis used in the field of medicineare valuable methods for evaluation of hypotheses within the health care areaand a good basis for decision-making.

Place, publisher, year, edition, pages
Stockholm: KTH, 2010. 51 p.
Trita-TEC-PHD, ISSN 1653-4468 ; 10:004
risk analysis, risk, consequence, system, biostatistics, decision, decision-making, health care, medicine
National Category
Medical Laboratory and Measurements Technologies
urn:nbn:se:kth:diva-24304 (URN)978-91-8559-62-8 (ISBN)
Public defence
2010-09-15, F3, Lindstedtsvägen 26, KTH, Stockholm, 10:15 (English)
QC20100901Available from: 2010-09-01 Created: 2010-09-01 Last updated: 2010-09-01Bibliographically approved

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