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Reliable in-vivo penetration and transdermal injection using ultra-sharp hollow microneedles
KTH, School of Electrical Engineering (EES), Microsystem Technology.
KTH, School of Electrical Engineering (EES), Microsystem Technology.
KTH, School of Electrical Engineering (EES), Microsystem Technology.ORCID iD: 0000-0001-9552-4234
2005 (English)In: Transducers '05, Digest of Technical Papers, Vols 1 and 2: Digest of Technical Papers, NEW YORK: IEEE , 2005, 213-216 p.Conference paper (Other academic)
Abstract [en]

Minimally invasive microneedles is a promising technology for painless drug administration through the human skin. However, not all microneedle structures are capable to penetrate human skin in a repeatable and reliable fashion at moderate insertion forces. In this work we present an ultra-sharp hollow microneedle array, tailored for enhanced and reliable skin penetration capability. The microneedle apex has a tip radius below 100 nm. We show penetration and sustainable injection of liquid dye into dry living human skin without the use of any penetration enhancers. Microneedle liquid injection was also tested on clinically relevant sites, such as the shoulder and the upper arm. The electrical impedance was measured between the microneedle and a counter electrode showing continuous changes in the measured values during the insertion.

Place, publisher, year, edition, pages
NEW YORK: IEEE , 2005. 213-216 p.
Keyword [en]
microneedles, drug delivery, skin penetration
URN: urn:nbn:se:kth:diva-24785DOI: 10.1109/SENSOR.2005.1496396ISI: 000232189100053ScopusID: 2-s2.0-27544493152ISBN: 0-7803-8994-8OAI: diva2:355208
13th International Conference on Solid-State Sensors, Actuators and Microsystems Seoul, SOUTH KOREA, JUN 05-09, 2005
QC 20101006Available from: 2010-10-06 Created: 2010-09-27 Last updated: 2010-10-06Bibliographically approved

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Roxhed, NiclasGriss, PatrickStemme, Göran
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