Rational redesign of Candida antarctica lipase B for the ring opening polymerization of D,D-lactide
2011 (English)In: Chemical Communications, ISSN 1359-7345, E-ISSN 1364-548X, Vol. 47, no 26, 7392-7394 p.Article in journal (Refereed) Published
Based on molecular modelling, the enzyme Candida antarctica lipase B was redesigned as a catalyst for the ring opening polymerization of D, D-lactide. Two mutants with 90-fold increased activity as compared to the wild-type enzyme were created. In a preparative synthesis of poly(D,D-lactide) the mutants greatly improved the rate and the degree of polymerization.
Place, publisher, year, edition, pages
2011. Vol. 47, no 26, 7392-7394 p.
LACTIDE, POLY(LACTIDE-CO-GLYCOLIDE), POLYLACTIDES, POLYESTERS
Biochemistry and Molecular Biology
IdentifiersURN: urn:nbn:se:kth:diva-25043DOI: 10.1039/c1cc10865dISI: 000291823400028ScopusID: 2-s2.0-79959407879OAI: oai:DiVA.org:kth-25043DiVA: diva2:355259
FunderEU, FP7, Seventh Framework Programme, IRENE, contract no. 227279, FP7-KBBE-2008-2B
QC 20101006 Updated from manuscript to article in journal2010-10-062010-10-062011-07-04Bibliographically approved