Change search
ReferencesLink to record
Permanent link

Direct link
Generic leak-free drug storage and delivery for microneedle-based systems
KTH, School of Electrical Engineering (EES), Microsystem Technology.
KTH, School of Electrical Engineering (EES), Microsystem Technology.
KTH, School of Electrical Engineering (EES), Microsystem Technology.ORCID iD: 0000-0001-9552-4234
2005 (English)In: MEMS 2005 Miami: Technical Digest, 2005, 742-745 p.Conference paper (Refereed)
Abstract [en]

We present a generic liquid packaging method for micromachined drug delivery systems with microneedles. Hollow microneedles are sealed with thin gold membranes at the openings on the needle tip on wafer level. This provides both a seal and an evaporation barrier to the drug delivery system on chip level. In addition, the membranes may also prevent drug delivery through needles that do not pierce the skin tissue. Applying a small voltage to the microneedle chip pressed onto the skin causes an electrochemical dissolving of membranes only at the needles that penetrated the skin tissue. The gold membrane sealed microneedles where tested for two types of operational modes. Opening the membranes by means of pressure showed that a minimum pressure of 125 kPa is needed to burst open the membranes. The removal of the gold membrane seal electrochemically was tested in vitro. The microneedle chip was opened within 2 min in the presence of an electrolyte comparable to the interstitial fluid.

Place, publisher, year, edition, pages
2005. 742-745 p.
URN: urn:nbn:se:kth:diva-24778ISI: 000228430000184ScopusID: 2-s2.0-26844532913ISBN: 0-7803-8732-5OAI: diva2:355356
18th IEEE International Conference on Micro Electro Mechanical Systems (MEMS) Miami Beach, FL, JAN 30-FEB 03, 2005
QC 20101006Available from: 2010-10-06 Created: 2010-09-27 Last updated: 2010-10-06Bibliographically approved

Open Access in DiVA

No full text


Search in DiVA

By author/editor
Roxhed, NiclasGriss, PatrickStemme, Göran
By organisation
Microsystem Technology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Total: 13 hits
ReferencesLink to record
Permanent link

Direct link