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MEMS for medical technology applications
KTH, School of Electrical Engineering (EES), Microsystem Technology (Changed name 20121201).ORCID iD: 0000-0002-3996-9279
KTH, School of Electrical Engineering (EES), Microsystem Technology (Changed name 20121201).
KTH, School of Electrical Engineering (EES), Microsystem Technology (Changed name 20121201).ORCID iD: 0000-0001-9552-4234
2007 (English)In: MEMS Adaptive Optics / [ed] Olivier, S.S., Bifano T.G., Kubby J.A., 2007, Vol. 6467, 46513-46513 p.Conference paper, Published paper (Refereed)
Abstract [en]

This paper gives an in-depth description of two recent projects at the Royal Institute of Technology (KTH) which utilize MEMS and microsystem technology for realization of components intended for specific applications in medical technology and diagnostic instrumentation. By novel use of the DRIE fabrication technology we have developed side-opened out-of-plane silicon microneedles intended for use in transdermal drug delivery applications. The side opening reduces clogging probability during penetration into the skin and increases the up-take area of the liquid in the tissue. These microneedles offer about 200 mu m deep and pain-free skin penetration. We have been able to combine the microneedle chip with an electrically and heat controlled liquid actuator device where expandable microspheres are used to push doses of drug liquids into the skin. The entire unit is made of low cost materials in the form of a square one cm-sized patch. Finally, the design, fabrication and evaluation of an integrated miniaturized Quartz Crystal Microbalance (QCM) based "electronic nose" microsystem for detection of narcotics is described. The work integrates a novel environment-to-chip sample interface with the sensor element. The choice of multifunctional materials and the geometric features of a four-component microsystem allow a functional integration of a QCM crystal, electrical contacts, fluidic contacts and a sample interface in a single system with minimal assembly effort, a potential for low-cost manufacturing, and a few orders of magnitude reduced in system size (12*12*4 mm) and weight compared to commercially available instruments. The sensor chip was successfully used it for the detection of 200 ng of narcotics sample.

Place, publisher, year, edition, pages
2007. Vol. 6467, 46513-46513 p.
Series
PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS, ISSN 0277-786X ; 6464
Keyword [en]
MEMS, microneedles, QCM, drug delivery, electronic nose
National Category
Electrical Engineering, Electronic Engineering, Information Engineering
Identifiers
URN: urn:nbn:se:kth:diva-24766DOI: 10.1117/12.716948ISI: 000246079300001Scopus ID: 2-s2.0-34249057775ISBN: 978-0-8194-6580-1 (print)OAI: oai:DiVA.org:kth-24766DiVA: diva2:357625
Conference
Conference on MEMS Adaptive Optics San Jose, CA, JAN 24-25, 2007
Note

QC 20101019. Invited Key Note Speaker

Available from: 2010-10-19 Created: 2010-09-27 Last updated: 2013-11-19Bibliographically approved

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Stemme, Göran

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