Real-time label-free biosensing with integrated planar waveguide ring-resonators
2010 (English)In: SILICON PHOTONICS AND PHOTONIC INTEGRATED CIRCUITS II / [ed] Giancarlo C. Righini, 2010, Vol. 7719, 77190B-1-77190B-15 p.Conference paper (Refereed)
We review the use of planar integrated optical waveguide ring resonators for label free bio-sensing and present recent results from two European biosensor collaborations: SABIO and InTopSens. Planar waveguide ring resonators are attractive for label-free biosensing due to their small footprint, high Q-factors, and compatibility with on-chip optics and microfluidics. This enables integrated sensor arrays for compact labs-on-chip. One application of label-free sensor arrays is for point-of-care medical diagnostics. Bringing such powerful tools to the single medical practitioner is an important step towards personalized medicine, but requires addressing a number of issues: improving limit of detection, managing the influence of temperature, parallelization of the measurement for higher throughput and on-chip referencing, efficient light-coupling strategies to simplify alignment, and packaging of the optical chip and integration with microfluidics. From the SABIO project we report refractive index measurement and label-free biosensing in an 8-channel slot-waveguide ring resonator sensor array, within a compact cartridge with integrated microfluidics. The sensors show a volume sensing detection limit of 5x10(-6) RIU and a surface sensing detection limit of 0.9 pg/mm(2). From the InTopSens project we report early results on silicon-on-insulator racetrack resonators.
Place, publisher, year, edition, pages
2010. Vol. 7719, 77190B-1-77190B-15 p.
, Proceedings of SPIE-The International Society for Optical Engineering, ISSN 0277-786X ; 7719
slot waveguide, ring resonators, label-free, biosensing, lab-on-chip, light-coupling, packaging, microfluidics
Electrical Engineering, Electronic Engineering, Information Engineering
IdentifiersURN: urn:nbn:se:kth:diva-25354DOI: 10.1117/12.855957ISI: 000285297700007ScopusID: 2-s2.0-77954730182ISBN: 978-0-8194-8192-4OAI: oai:DiVA.org:kth-25354DiVA: diva2:358599
Conference on Silicon Photonics and Photonic Integrated Circuits II Location: Brussels, BELGIUM Date: APR 12-16, 2010
QC 201010222010-10-222010-10-192011-11-23Bibliographically approved