Diastereoselective addition of organozinc reagents to 2-alkyl-3-(arylsulfanyl)propanals
2004 (English)In: Tetrahedron, ISSN 0040-4020, E-ISSN 1464-5416, Vol. 60, no 47, 10659-10669 p.Article in journal (Refereed) Published
The preparation of compounds incorporating the 3-hydroxy-2-methyl-1-alkyl moiety of high diastereomeric purity is described. Such compounds can serve as potential building blocks for the preparation of several kinds of natural products. Diastereoselective synthesis of two potential pine sawfly pheromone components, one the pure racemic threo-isomer of 3-methylpentadecan-2-ol and the other the racemic erythro-isomer of 3-methyltridecan-2-ol are described. The diastereoselective addition of R2Zn (R = Me, Et and n-Bu) to several 2-alkyl-3-(arylsulfanyl)propanals in the presence of a Lewis acid and CH2Cl2 as solvent was studied. An excellent diastereomeric ratio (95/5 anti-Cram/Cram) was obtained with 2-[(phenylsulfanyl)methyl]pentanal, 2-[(phenylsulfanyl)methyl]decanal and 2-[(phenylsulfanyl)methyl]dodecanal and Me2Zn in the presence of TiCl4.
Place, publisher, year, edition, pages
2004. Vol. 60, no 47, 10659-10669 p.
diastereoselective additions, dimethylzinc, titanium tetrachloride, chelation, pheromones
IdentifiersURN: urn:nbn:se:kth:diva-25547DOI: 10.1016/j.tet.2004.09.005ISI: 000224715100008OAI: oai:DiVA.org:kth-25547DiVA: diva2:359106
QC 201010262010-10-262010-10-262010-10-26Bibliographically approved