Linear dendritic polymeric amphiphiles with intrinsic biocompatibility: synthesis and characterization to fabrication of micelles and honeycomb membranes
2011 (English)In: Polymer Chemistry, ISSN 1759-9954, Vol. 2, 394-402 p.Article in journal (Refereed) Published
Linear dendritic hybrid materials enable a range of architectural variations which offers novel possibilities in the tailoring of polymeric materials. In this study dendrons based on the 2,2-bis(methylol)propionic acid (bis-MPA) building block, bearing click chemistry moieties in the core and peripheral hydroxyl functionalities, have been used as macroinitiators for ring opening polymerization of ε-caprolactone. A library of star branched polymers with poly(ε-caprolactone) chains was initially constructed using dendrons up to 4th generation. In a second step, the popular CuAAC or thiol–ene click reaction was efficiently used to attach poly(ethylene glycol) chains of different lengths to the core. Potential applications of the resulted amphiphilic linear dendritic hybrids were investigated. Both self-assembled micelles loaded with doxorubicin anticancer drug and ordered honeycomb membranes with enhanced surface area were successfully fabricated and characterized.
Place, publisher, year, edition, pages
2011. Vol. 2, 394-402 p.
IdentifiersURN: urn:nbn:se:kth:diva-26392DOI: 10.1039/C0PY00258EISI: 000286327400019ScopusID: 2-s2.0-78751533187OAI: oai:DiVA.org:kth-26392DiVA: diva2:372411
FunderSwedish Research Council, 2009-3259Swedish Research Council, 2006-3617Knut and Alice Wallenberg Foundation
QC 201011252010-11-252010-11-252013-03-27Bibliographically approved