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Does indomethacin for closure of patent ductus arteriosus affect cerebral function?
Department of Pediatrics, Queen Silvia Children's Hospital, Sahlgrenska University Hospital-Östra.
Department of Pediatrics, Queen Silvia Children's Hospital, Sahlgrenska University Hospital-Östra.
School of Engineering, University of Borås.
Neoventa Medical AB, Göteborg.
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2010 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 99, no 10, 1493-1497 p.Article in journal (Refereed) Published
Abstract [en]

Objective: To study whether indomethacin used in conventional dose for closure of patent ductus arteriosus affects cerebral function measured by Electroencephalograms (EEG) evaluated by quantitative measures. Study design: Seven premature neonates with haemodynamically significant persistent ductus arteriosus were recruited. EEG were recorded before, during and after an intravenous infusion of 0.2 mg/kg indomethacin over 10 min. The EEG was analysed by two methods with different degrees of complexity for the amount of low-activity periods (LAP, "suppressions") as an indicator of affection of cerebral function. Results: Neither of the two methods identified any change in the amount of LAPs in the EEG as compared to before the indomethacin infusion. Conclusion: Indomethacin in conventional dose for closure of patent ductus arteriosus does not affect cerebral function as evaluated by quantitative EEG.

Place, publisher, year, edition, pages
2010. Vol. 99, no 10, 1493-1497 p.
Keyword [en]
BIRTH-WEIGHT INFANTS, PRETERM INFANTS, INTRAVENTRICULAR HEMORRHAGE, PREMATURE-INFANTS, HEMODYNAMICS, TRIAL, OXYGENATION, PREVENTION, IBUPROFEN, PROPHYLAXIS
National Category
Medical and Health Sciences Pediatrics
Identifiers
URN: urn:nbn:se:kth:diva-26714DOI: 10.1111/j.1651-2227.2010.01857.xISI: 000281556700016Scopus ID: 2-s2.0-77956357318OAI: oai:DiVA.org:kth-26714DiVA: diva2:372670
Note

QC 20150727

Available from: 2010-11-26 Created: 2010-11-26 Last updated: 2017-12-12Bibliographically approved

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