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Differential conductance as a promising approach for rapid DNA sequencing with nanopore-embedded electrodes
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2010 (English)In: Applied Physics Letters, ISSN 0003-6951, E-ISSN 1077-3118, Vol. 97, no 4, 043701- p.Article in journal (Refereed) Published
Abstract [en]

We propose an approach for nanopore-based DNA sequencing using characteristic transverse differential conductance. Molecular dynamics and electron transport simulations show that the transverse differential conductance during the translocation of DNA through the nanopore is distinguishable enough for the detection of the base sequence and can withstand electrical noise caused by DNA structure fluctuation. Our findings demonstrate several advantages of the transverse conductance approach, which may lead to important applications in rapid genome sequencing. (C) 2010 American Institute of Physics. [doi: 10.1063/1.3467194]

Place, publisher, year, edition, pages
2010. Vol. 97, no 4, 043701- p.
Keyword [en]
bioelectric phenomena, biological techniques, DNA, electrodes, electrophoresis, genomics, molecular biophysics, molecular dynamics method, nanobiotechnology, nanoporous materials
National Category
Physical Sciences
Identifiers
URN: urn:nbn:se:kth:diva-26861DOI: 10.1063/1.3467194ISI: 000281059200101Scopus ID: 2-s2.0-77955742701OAI: oai:DiVA.org:kth-26861DiVA: diva2:373722
Note
QC 20101201Available from: 2010-12-01 Created: 2010-11-29 Last updated: 2017-12-12Bibliographically approved

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