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Theoretical Bounds and System Design for Multipinhole SPECT
KTH, School of Engineering Sciences (SCI), Physics, Medical Imaging.ORCID iD: 0000-0002-7725-0548
KTH, School of Engineering Sciences (SCI), Physics, Medical Imaging.ORCID iD: 0000-0002-3039-9791
2010 (English)In: IEEE Transactions on Medical Imaging, ISSN 0278-0062, E-ISSN 1558-254X, Vol. 29, no 7, p. 1390-1400Article in journal (Refereed) Published
Abstract [en]

The pinhole camera in single photon emission computed tomography (SPECT) has an inherent trade-off between resolution and sensitivity. Recent systems overcome this to some extent by utilizing multiple pinholes distributed around the imaging object. The present work is a theoretical study on how to optimally construct such systems. We use an analytic model to analyze the multipinhole SPECT geometry and identify the underlying trade-offs. One of the results is the derivation of the upper bound for the sensitivity, given the geometric resolution and field-of-view (FOV). Reaching this bound requires an infinitely large detector. However, a sensitivity very close to the upper bound can be achieved by a system with realistic proportions. We show that it is usually possible to get a sensitivity that is 95%-99% of the upper bound. Further analysis reveals a trade-off between sensitivity, magnification, and the number of pinholes. Based on this new theory, we develop a strategy for multipinhole SPECT design, from which a number of example systems are computed. Penetration in the pinhole knife edge is accounted for by using the resolution and sensitivity equivalent apertures.

Place, publisher, year, edition, pages
2010. Vol. 29, no 7, p. 1390-1400
Keywords [en]
Multipinhole collimator, single photon emission computed tomography (SPECT), small-animal imaging, system analysis and design
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:kth:diva-26642DOI: 10.1109/TMI.2010.2047113ISI: 000281925700005Scopus ID: 2-s2.0-77954234753OAI: oai:DiVA.org:kth-26642DiVA, id: diva2:374316
Note
QC 20101203Available from: 2010-12-03 Created: 2010-11-26 Last updated: 2017-12-12Bibliographically approved

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