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Affibody molecules: Engineered proteins for therapeutic, diagnostic and biotechnological applications
KTH, School of Biotechnology (BIO), Molecular Biotechnology.ORCID iD: 0000-0001-9423-0541
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2010 (English)In: FEBS Letters, ISSN 0014-5793, E-ISSN 1873-3468, Vol. 584, no 12, 2670-2680 p.Article, review/survey (Refereed) Published
Abstract [en]

Affibody molecules are a class of engineered affinity proteins with proven potential for therapeutic, diagnostic and biotechnological applications. Affibody molecules are small (6.5 kDa) single domain proteins that can be isolated for high affinity and specificity to any given protein target. Fifteen years after its discovery, the Affibody technology is gaining use in many groups as a tool for creating molecular specificity wherever a small, engineering compatible tool is warranted. Here we summarize recent results using this technology, propose an Affibody nomenclature and give an overview of different HER2-specific Affibody molecules. Cumulative evidence suggests that the three helical scaffold domain used as basis for these molecules is highly suited to create a molecular affinity handle for vastly different applications.

Place, publisher, year, edition, pages
2010. Vol. 584, no 12, 2670-2680 p.
Keyword [en]
Affibody molecule, Alternative scaffold, Biotherapy, Molecular imaging, Combinatorial protein engineering, Phage display
National Category
Industrial Biotechnology
URN: urn:nbn:se:kth:diva-27592DOI: 10.1016/j.febslet.2010.04.014ISI: 000278031800022ScopusID: 2-s2.0-77953130101OAI: diva2:377417
QC 20101214Available from: 2010-12-14 Created: 2010-12-13 Last updated: 2010-12-14Bibliographically approved

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