Enantioselective Synthesis of anti-beta-Hydroxy-alpha-amido Esters via Transfer Hydrogenation
2010 (English)In: Organic Letters, ISSN 1523-7060, E-ISSN 1523-7052, Vol. 12, no 22, 5274-5277 p.Article in journal (Refereed) Published
The asymmetric transfer hydrogenation of alpha-amido-beta-keto esters to provide the corresponding anti-beta-hydroxy-alpha-amido esters in good to excellent yields, diastereoselectivity, and enantioselectivity is reported. The procedure is operationally simple, and delicate handling of the catalyst is not necessary.
Place, publisher, year, edition, pages
2010. Vol. 12, no 22, 5274-5277 p.
dynamic kinetic resolution, asymmetric transfer hydrogenation, amino acid-derivatives, aldol reactions, stereoselective hydrogenation, catalyzed hydrogenation, functionalized ketones, efficient approach, organic-synthesis, aldehydes
IdentifiersURN: urn:nbn:se:kth:diva-27357DOI: 10.1021/ol102323kISI: 000284080400050ScopusID: 2-s2.0-78449267573OAI: oai:DiVA.org:kth-27357DiVA: diva2:377555
FunderKnut and Alice Wallenberg FoundationSwedish Research Council
QC 201012142010-12-142010-12-132012-06-05Bibliographically approved