Multilayered polyelectrolyte-coated gold nanorods as multifunctional optical contrast agents for cancer cell imaging
2010 (English)In: Journal of Zhejiang University: Science B, ISSN 1673-1581, Vol. 11, no 6, 417-422 p.Article in journal (Refereed) Published
We report the application of multilayered polyelectrolyte-coated gold nanorods (GNRs) as multifunctional optical contrast agents for cancer cell imaging. The surface modification of GNRs improves their chemical stability and facilitates them to be taken up by cancer cells through electrostatic interaction. The unique longitudinal surface plasmon resonance property of GNRs makes them suitable as both "scattering contrast agents" and "Raman contrast agents". In our experiments, the staining of GNRs in cells was further confirmed by dark field microscopy and Raman microscopy. Our experiment results indicated that GNRs have great potential as multifunctional "optical contrast agents" for future in vivo animal imaging.
Place, publisher, year, edition, pages
2010. Vol. 11, no 6, 417-422 p.
Gold nanorods, Polyelectrolyte, Scattering, Raman, Cancer cell imaging
Electrical Engineering, Electronic Engineering, Information Engineering
IdentifiersURN: urn:nbn:se:kth:diva-27579DOI: 10.1631/jzus.B0910731ISI: 000278156000003ScopusID: 2-s2.0-77954683381OAI: oai:DiVA.org:kth-27579DiVA: diva2:377684
QC 201012142010-12-142010-12-132013-11-19Bibliographically approved