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Multilayered polyelectrolyte-coated gold nanorods as multifunctional optical contrast agents for cancer cell imaging
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2010 (English)In: Journal of Zhejiang University: Science B, ISSN 1673-1581, Vol. 11, no 6, 417-422 p.Article in journal (Refereed) Published
Abstract [en]

We report the application of multilayered polyelectrolyte-coated gold nanorods (GNRs) as multifunctional optical contrast agents for cancer cell imaging. The surface modification of GNRs improves their chemical stability and facilitates them to be taken up by cancer cells through electrostatic interaction. The unique longitudinal surface plasmon resonance property of GNRs makes them suitable as both "scattering contrast agents" and "Raman contrast agents". In our experiments, the staining of GNRs in cells was further confirmed by dark field microscopy and Raman microscopy. Our experiment results indicated that GNRs have great potential as multifunctional "optical contrast agents" for future in vivo animal imaging.

Place, publisher, year, edition, pages
2010. Vol. 11, no 6, 417-422 p.
Keyword [en]
Gold nanorods, Polyelectrolyte, Scattering, Raman, Cancer cell imaging
National Category
Electrical Engineering, Electronic Engineering, Information Engineering
Identifiers
URN: urn:nbn:se:kth:diva-27579DOI: 10.1631/jzus.B0910731ISI: 000278156000003Scopus ID: 2-s2.0-77954683381OAI: oai:DiVA.org:kth-27579DiVA: diva2:377684
Note
QC 20101214Available from: 2010-12-14 Created: 2010-12-13 Last updated: 2013-11-19Bibliographically approved

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He, Sailing

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