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A theoretical investigation of the supersaturation of basic calcium phosphate in serum of dialysis patients
KTH, School of Chemical Science and Engineering (CHE), Chemistry.
KTH, School of Chemical Science and Engineering (CHE), Chemistry, Inorganic Chemistry (closed 20110630).
2006 (English)In: Journal of Applied Biomaterials and Biomechanics, ISSN 1722-6899, Vol. 4, no 2, 80-86 p.Article, review/survey (Refereed) Published
Abstract [en]

Extraosseous calcification in hemodialysis (HD) patients consists mainly of biological apatite, idealized as hydroxyapatite. Other suggested calcium phosphates are octacalcium phosphate (OCP) and brushite, both known to be hydroxyapatite precursors. Whatever the mechanisms of mineral deposition are, these mechanisms are always required to produce a supersaturated state, and that state can be calculated from the solubility product (SP) of the relevant mineral. Supersaturation in relation to serum ionized calcium [Ca2+] and total inorganic serum phosphate (Pi) under normal and hyperphosphatemic conditions has been calculated. While supersaturation with respect to hydroxyapatite and OCP always exists, and supersaturation with respect to Ca5(PO4)3(HCO3)·4H2O is just above the limit, supersaturation with respect to brushite solely occurs under hyperphosphatemic conditions. In order to avoid supersaturation with respect to brushite the maximum serum phosphate level allowed is 1.9 mmol/L (5.8 mg/dl) and the calcium-phosphate product (Ca x— P) 4.5 (mmol/L)2 (56 (mg/dl))2.

Place, publisher, year, edition, pages
2006. Vol. 4, no 2, 80-86 p.
Keyword [en]
Biomineralization, Brushite, Calcification, Calcium phosphate, Hyperphosphatemia, calcium, hydroxyapatite, phosphate, calcium blood level, hemodialysis patient, human, phosphate blood level, review
National Category
Inorganic Chemistry
Identifiers
URN: urn:nbn:se:kth:diva-27710PubMedID: 20799206Scopus ID: 2-s2.0-33749648142OAI: oai:DiVA.org:kth-27710DiVA: diva2:379951
Note

QC 20101220

Available from: 2010-12-20 Created: 2010-12-20 Last updated: 2014-04-07Bibliographically approved
In thesis
1. Calcium phosphate precipitation in blood serum model solutions
Open this publication in new window or tab >>Calcium phosphate precipitation in blood serum model solutions
2005 (English)Licentiate thesis, comprehensive summary (Other scientific)
Place, publisher, year, edition, pages
Stockholm: KTH, 2005. xiv, 45 p.
Series
Trita-OOK, ISSN 0348-825X ; 1082
National Category
Inorganic Chemistry
Identifiers
urn:nbn:se:kth:diva-576 (URN)91-7178-217-6 (ISBN)
Presentation
2005-12-15, sal K2, KTH, Teknikringen 28, Stockholm, 14:00
Opponent
Supervisors
Note
QC 20101220Available from: 2005-12-28 Created: 2005-12-28 Last updated: 2010-12-20Bibliographically approved

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