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Structure-Reactivity Relationship Studies for Guanidine-Organocatalyzed Direct Intramolecular Aldolization of Ketoaldehydes
KTH, School of Biotechnology (BIO), Theoretical Chemistry.
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2010 (English)In: CHEMCATCHEM, ISSN 1867-3880, Vol. 2, no 12, 1573-1581 p.Article in journal (Refereed) Published
Abstract [en]

Structure-reactivity studies are performed to explore the reaction mechanism of the guanidine-catalyzed intramolecular aldol reaction of ketoaldehydes. A large number of guanidine and guanidine-like catalysts are synthesized and their properties studied. Kinetic profiles and pK(a) values of the catalysts are measured and correlated to reaction barriers calculated using density functional theory (DFT). The DFT calculations show that structural rigidity influences the pKa of the guanidines. Although the basicity is a very important factor in the catalysis, it is not sufficient to fully account for its catalytic efficiency. The availability of two aligned nitrogen reaction sites for proton shuttling in the transition state is an essential feature that helps to rationalize the reactivity pattern and the activation mode for this family of organocatalysts.

Place, publisher, year, edition, pages
2010. Vol. 2, no 12, 1573-1581 p.
Keyword [en]
aldolization, density functional calculations, organocatalysis, regioselectivity, structure-activity relationships
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:kth:diva-27689DOI: 10.1002/cctc.201000227ISI: 000284717800014Scopus ID: 2-s2.0-79957884399OAI: oai:DiVA.org:kth-27689DiVA: diva2:380290
Funder
Swedish Research Council
Note
QC 20101221Available from: 2010-12-21 Created: 2010-12-20 Last updated: 2010-12-21Bibliographically approved

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