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In vivo biodistribution and efficacy of peptide mediated delivery
KTH, School of Biotechnology (BIO), Molecular Biotechnology.
2010 (English)In: TIPS - Trends in Pharmacological Sciences, ISSN 0165-6147, E-ISSN 1873-3735, Vol. 31, no 11, 528-535 p.Article, review/survey (Refereed) Published
Abstract [en]

To transverse the plasma membrane and gain access to the cellular interior is one of the major obstacles for many novel pharmaceutical molecules. Since the late 1990 s, cell-penetrating peptides (CPPs) have been utilized as transport vectors for a broad spectrum of 'biological cargoes', ranging from inert gold particles to multifaceted macromolecules such as proteins and plasmids. Numerous studies have shown that CPPs are efficient carriers for bioactive cargoes in vitro. However, even though CPPs are versatile transport vectors, this does not guarantee they can be developed into useful pharmaceutical molecules. Nevertheless, recent progress in the field has shown CPPs to be effective for in vivo delivery with retained biological activity of a wide variety of bioactive cargoes into virtually any mammalian tissue. This review will focus on recent developments and applications for CPP delivery and distribution in vivo.

Place, publisher, year, edition, pages
2010. Vol. 31, no 11, 528-535 p.
National Category
Biochemistry and Molecular Biology
URN: urn:nbn:se:kth:diva-27653DOI: 10.1016/ 000284499900005ScopusID: 2-s2.0-77958153239OAI: diva2:381101
Swedish Research CouncilKnut and Alice Wallenberg Foundation
QC 20101223Available from: 2010-12-23 Created: 2010-12-20 Last updated: 2010-12-23Bibliographically approved

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