Botulinumtoxin A treatment in toddlers with cerebral palsy
2010 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 99, no 8, 1156-1162 p.Article in journal (Refereed) Published
Aims: In this study the aim was to evaluate the effect of botulinum toxin A (BoNT-A) treatment on muscle tone, contracture development and gait pattern in young children with cerebral palsy (CP). Method: Fifteen children with spastic CP (mean age = 16 months) were included in a randomized control study. All received a daily stretching programme and children in the BoNT-A group additionally received two injections, 6 months apart in the gastrocnemius muscle. Outcomes were assessed at baseline, and after 1 and 3.5 years. A 3D gait-analysis was performed at 5 years of age. Results: Plantarflexor muscle tone in the BoNT-A group was significantly reduced after 3.5 years, while the muscle tone at the ankle and knee in the control group remained unchanged. The change-score in knee-flexion muscle tone between the groups was significantly different after 3.5 years. The knee joint ROM was significantly increased at 1 year in the BoNT-A group but reduced at the knee and ankle joints in the control group after 3.5 years. No group differences were found for gait analysis, GMFM-66 or PEDI. Conclusion: Early treatment of BoNT-A in children with spastic CP may decrease muscle tone and decelerate contracture development after 3.5 years. The effect on gait development remains inconclusive.
Place, publisher, year, edition, pages
2010. Vol. 99, no 8, 1156-1162 p.
Botulinum toxin A, Cerebral palsy, Contracture, Gait, Long term
IdentifiersURN: urn:nbn:se:kth:diva-27253DOI: 10.1111/j.1651-2227.2010.01767.xISI: 000279438000012ScopusID: 2-s2.0-77954372048OAI: oai:DiVA.org:kth-27253DiVA: diva2:381416
QC 201012272010-12-272010-12-092010-12-27Bibliographically approved