Intima-Media Thickness of Common Carotid and Brachial Arteries and Prothrombin Fragment 1+2 Are Associated with Left Ventricular Diastolic Dysfunction in Patients with Myocardial Infarction
2010 (English)In: Echocardiography, ISSN 0742-2822, E-ISSN 1540-8175, Vol. 27, no 6, 651-658 p.Article in journal (Refereed) Published
Aims: To investigate the association between intima-media thickness of brachial and common carotid arteries and factors of the coagulation- and fibrinolysis-system with left ventricular diastolic dysfunction in patients with a previous myocardial infarction. Patients and methods: One hundred and twenty three patients, men (76%) and women (24%) aged between 32and 81 years with a history of previous acute myocardial infarction were included. B-mode ultrasound of common carotid and brachial arteries and echocardiography with tissue Doppler imaging (TDI) were evaluated. Factors of the coagulation- and fibrinolysis-system were also measured. Results: In patients with previous myocardial infarction, late diastolic filling time was significantly and positively associated with log Prothrombin fragment 1 + 2 (P < 0.001) and with calculated intima-media area (cIMa) of the both common carotid and brachial arteries (P < 0.05). Mitral early-to-late flow velocity ratio (E/A) was significantly and negatively associated with log Prothrombin fragment 1 + 2 (P < 0.001), total cholesterol and cIMa of the both common carotid and brachial arteries (P < 0.05). Moreover both late diastolic filling time and mitral E/A correlated significantly with age and systolic blood pressure. In stepwise multiple regression analysis, log Prothrombin fragment 1 + 2 remained the only variable with independent significant correlation to late diastolic filling time and mitral E/A. Conclusions: In a population sample of patients with myocardial infarction, late diastolic filling time and mitral E/A were associated with cIMa of common carotid and brachial arteries, systolic blood pressure, and prothrombin fragment 1 + 2, suggesting a relationship between diastolic dysfunction, thrombin generation and atherosclerosis. (Echocardiography 2010;27:651-658).
Place, publisher, year, edition, pages
2010. Vol. 27, no 6, 651-658 p.
tissue Doppler imaging, Prothrombin fragment 1+2
Medical Laboratory and Measurements Technologies
IdentifiersURN: urn:nbn:se:kth:diva-27224DOI: 10.1111/j.1540-8175.2009.01095.xISI: 000279718700012ScopusID: 2-s2.0-77954559269OAI: oai:DiVA.org:kth-27224DiVA: diva2:381877
QC 201012292010-12-292010-12-092010-12-29Bibliographically approved