Synthesis and DNA photocleavage study of Ru(bpy)(3)(2+)-(CH2)(n)-MV2+ complexes
2010 (English)In: Dalton Transactions, ISSN 1477-9226, E-ISSN 1477-9234, Vol. 39, no 18, 4411-4416 p.Article in journal (Refereed) Published
A series of Ru(bpy)(3)(2+)-(CH2)(n)-MV2+ complexes (1, n = 3, 4, 7) used for DNA photocleavage have been designed and synthesized. Under the irradiation of visible light, complexes 1 can cleave supercoiled plasmid DNA (pBR322) both in air and under Ar atmosphere. Radical species such as O2(-center dot), (OH)-O-center dot and the light-induced charge-separated (CS) oxidation state Ru(bpy)(3)(3+)-(CH2)(n)-MV+center dot are responsible for the cleavage. The longer the carbon chain linkage, the higher the DNA photocleavage efficiency. It is noted that backwards intramolecular electron transfer (ET) that exist in complexes 1 can lead to some decreasing effect on the cleavage result, while inclusion of complexes 1 with cucurbituril (CB) inhibits the backwards ET to some extent, thereby increasing photocleavage efficiency.
Place, publisher, year, edition, pages
2010. Vol. 39, no 18, 4411-4416 p.
FLASH-QUENCH TECHNIQUE, PHOTOINDUCED ELECTRON-TRANSFER, MIXED-LIGAND COMPLEXES, ARTIFICIAL PHOTOSYNTHESIS, MOLECULAR TRIAD, DONOR-ACCEPTOR, OXIDATION, GUANINE, BINDING, CHEMISTRY
IdentifiersURN: urn:nbn:se:kth:diva-28257DOI: 10.1039/b927568aISI: 000277031800020ScopusID: 2-s2.0-77951600785OAI: oai:DiVA.org:kth-28257DiVA: diva2:387629
QC 201101142011-01-142011-01-122011-01-14Bibliographically approved