Change search
ReferencesLink to record
Permanent link

Direct link
Three-Dimensional Geometrical Characterization of Abdominal Aortic Aneurysms: Image-Based Wall Thickness Distribution
Show others and affiliations
2009 (English)In: Journal of Biomechanical Engineering, ISSN 0148-0731, Vol. 131, no 6, 061015- p.Article in journal (Refereed) Published
Abstract [en]

The clinical assessment of abdominal aortic aneurysm (AAA) rupture risk is based on the quantification of AAA size by measuring its maximum diameter from computed tomography (CT) images and estimating the expansion rate of the aneurysm sac over time. Recent findings have shown that geometrical shape and size, as well as local wall thickness may be related to this risk; thus, reliable noninvasive image-based methods to evaluate AAA geometry have a potential to become valuable clinical tools. Utilizing existing CT data, the three-dimensional geometry of nine unruptured human AAAs was reconstructed and characterized quantitatively. We propose and evaluate a series of 1D size, 2D shape, 3D size, 3D shape, and second-order curvature-based indices to quantify AAA geometry, as well as the geometry of a size-matched idealized fusiform aneurysm and a patient-specific normal abdominal aorta used as controls. The wall thickness estimation algorithm, validated in our previous work, is tested against discrete point measurements taken from a cadaver tissue model, yielding an average relative difference in AAA wall thickness of 7.8%. It is unlikely that any one of the proposed geometrical indices alone would be a reliable index of rupture risk or a threshold for elective repair. Rather, the complete geometry and a positive correlation of a set of indices should be considered to assess the potential for rupture. With this quantitative parameter assessment, future research can be directed toward statistical analyses correlating the numerical values of these parameters with the risk of aneurysm rupture or intervention (surgical or endovascular). While this work does not provide direct insight into the possible clinical use of the geometric parameters, we believe it provides the foundation necessary for future efforts in that direction.

Place, publisher, year, edition, pages
2009. Vol. 131, no 6, 061015- p.
National Category
Industrial Biotechnology
URN: urn:nbn:se:kth:diva-29139DOI: 10.1115/1.3127256ISI: 000266035700015PubMedID: 19449969OAI: diva2:392531
QC 20110127Available from: 2011-01-27 Created: 2011-01-27 Last updated: 2011-01-27Bibliographically approved
In thesis
1. Multiscale Modeling of the Normal and Aneurysmatic Abdominal Aorta
Open this publication in new window or tab >>Multiscale Modeling of the Normal and Aneurysmatic Abdominal Aorta
2010 (English)Licentiate thesis, comprehensive summary (Other academic)
Place, publisher, year, edition, pages
Stockholm: KTH, 2010. 20 p.
Trita-HFL. Report / Royal Institute of Technology, Solid Mechanics, ISSN 1654-1472 ; 0498
urn:nbn:se:kth:diva-28925 (URN)
2010-12-20, Sal D3, Lindstedtsvägen 5, KTH, Stockholm, 10:15 (English)

QC 20110127

Available from: 2011-01-27 Created: 2011-01-24 Last updated: 2013-01-15Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Martufi, Giampaolo
In the same journal
Journal of Biomechanical Engineering
Industrial Biotechnology

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 34 hits
ReferencesLink to record
Permanent link

Direct link