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Hypoxic preconditioning increases gap-junctional graft and host communication
KTH, School of Engineering Sciences (SCI), Applied Physics, Cell Physics.ORCID iD: 0000-0003-0578-4003
2010 (English)In: NeuroReport, ISSN 0959-4965, E-ISSN 1473-558X, Vol. 21, no 17, 1126-1132 p.Article in journal (Refereed) Published
Abstract [en]

Gap-junctional intercellular communication between grafted neural stem cells (NSCs) and host cells seems to be essential for many of the functional and beneficial interactions after NSC engraftment. Gap-junctional communication is also known to increase in the central nervous system after hypoxia and ischemia. We therefore hypothesized that controlled hypoxic preconditioning of murine NSCs (C17.2) before the engraftment is a reliable method to increase connexin 43 expression and improve subsequent graft and host communication. Data indicated that 3-h exposure to hypoxia increased the number of connexin 43 aggregates in treated NSCs by 31%. This was paralleled by enhanced hemichannel function showed by faster calcein dye efflux and an augmentation of the early functional graft and host communication.

Place, publisher, year, edition, pages
2010. Vol. 21, no 17, 1126-1132 p.
Keyword [en]
central nervous system, connexin, engraftment, gap junctions, hemichannels, hypoxia, interactions, neural stem cells, preconditioning, rescue
National Category
Neurosciences
Identifiers
URN: urn:nbn:se:kth:diva-26214DOI: 10.1097/WNR.0b013e328340a77bISI: 000283745400013Scopus ID: 2-s2.0-78349313802OAI: oai:DiVA.org:kth-26214DiVA: diva2:399883
Funder
Swedish Research Council, A0988, 04-5718, 05234
Note
QC 20110224Available from: 2011-02-24 Created: 2010-11-21 Last updated: 2017-12-11Bibliographically approved

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Brismar, Hjalmar

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